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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2010-9-21
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pubmed:abstractText |
The present study examined the effect of GLP-1(1-37) on chemokine-induced CD4-positive lymphocyte migration as an early and critical step in atherogenesis. Pretreatment with GLP-1(1-37) reduced the SDF-induced migration of isolated human CD4-positive lymphocytes in a concentration-dependent manner. Similar effects were seen when RANTES was used as a chemokine. GLP-1(1-37)'s effect on CD4-positive lymphocyte migration was mediated through an early inhibition of chemokine-induced PI-3 kinase activity. Downstream, GLP-1(1-37) inhibited SDF-induced phosphorylation of MLC and cofilin and limited f-actin formation as well as ICAM3 translocation. Furthermore, exendin-4 inhibited SDF-induced migration of CD4-positive lymphocytes similarly to GLP-1(1-37), and transfection of these cells with GLP-1 receptor siRNA abolished GLP-1(1-37)'s action on chemokine-induced ICAM3 translocation, suggesting an effect mediated via the GLP-1 receptor. Thus, GLP-1(1-37) inhibits chemokine-induced CD4-positive lymphocyte migration by inhibition of the PI3-kinase pathway and via the GLP-1 receptor. This effect provides a potential novel mechanism for how GLP-1(1-37) may modulate vascular disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actin Depolymerizing Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon-Like Peptide 1,
http://linkedlifedata.com/resource/pubmed/chemical/ICAM3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Light Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/glucagon-like peptide receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1420-9071
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3549-55
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20495843-Actin Depolymerizing Factors,
pubmed-meshheading:20495843-Actins,
pubmed-meshheading:20495843-Antigens, CD,
pubmed-meshheading:20495843-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20495843-Cell Adhesion Molecules,
pubmed-meshheading:20495843-Cell Movement,
pubmed-meshheading:20495843-Chemokine CXCL12,
pubmed-meshheading:20495843-Enzyme Activation,
pubmed-meshheading:20495843-Glucagon-Like Peptide 1,
pubmed-meshheading:20495843-Humans,
pubmed-meshheading:20495843-Myosin Light Chains,
pubmed-meshheading:20495843-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:20495843-Phosphorylation,
pubmed-meshheading:20495843-Protein Transport,
pubmed-meshheading:20495843-RNA, Small Interfering,
pubmed-meshheading:20495843-Receptors, Glucagon,
pubmed-meshheading:20495843-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Glucagon-like peptide-1(1-37) inhibits chemokine-induced migration of human CD4-positive lymphocytes.
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pubmed:affiliation |
Department of Internal Medicine I-Cardiology, University of Aachen, Pauwelstr. 30, Aachen, Germany. nmarx@ukaachen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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