Linked Life Data

20494887

Source:http://linkedlifedata.com/resource/pubmed/id/20494887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2010-5-24
pubmed:abstractText
The pathogenic role of oxidative stress has already been proven both in energy homeostasis and bone metabolism. The effects of +22348C>T (RS769217) polymorphism of catalase (EC 1.11.1.6, hydrogenperoxid-hydrogenperoxid oxidoreduktase) gene were investigated on glucose disposal and bone mineral density in groups of healthy (n = 24) and glucose intolerant (n = 27) females and healthy (n = 64) and glucose intolerant (n = 26) males. Glucose intolerant groups included IFG, IGT and non-treated type 2 diabetic patients. There were no differences in allele frequencies between the genders and groups in this transdanubian Hungarian population. The effects of CAT gene polymorphisms on glucose metabolism and bone status were gender specific. Females with mutant CAT (CT+TT) gene had better HOMA-IR (CC: 2.95+/-1.8 versus CT+TT: 2.06+/-0.9, p<0.05), but bone density did not differ between the CC and CT+TT haplotypes. The homozygote TT females had significantly better whole body glucose disposal. (M-1 mg/kg/min: CC: 9,43+/-4,4 versus TT: 13,23+/-1,6mg/kg body weight/min, p<0.05). The appearance of T allel among males caused lower femur density (CC: 1,11+/-0,17 versus CT+TT: 1,03+/-0,16, p<0.05 g/cm 2 ) and better HOMA-IR (CC: 2.42+/-2.3 versus CT+TT: 1.50+/-0.2, p<0.05), with no change in whole body glucose disposal. Osteocalcin - which has been proven to be the connection between energy homeostasis and bone metabolism - had identical serum levels in both haplotypes, but the significant correlation between muscle tissue glucose utilization and osteocalcin levels (r = +0.4424, p<0.05, n = 23) disappeared in the presence of T allele. Multiple correlation showed significant connection between leptin/adiponectin and femur BMD in CC female group, and between leptin/adiponectin and lumbar BMD in CC male group. The correlations disappeared with the appearance of T allele. Our results differ from the data obtained in Korean postmenopausal women and stress the need of population/ethnic specific replication of genetic data.
pubmed:language
hun
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0030-6002
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
923-31
pubmed:meshHeading
pubmed-meshheading:20494887-Adiponectin, pubmed-meshheading:20494887-Adult, pubmed-meshheading:20494887-Biological Markers, pubmed-meshheading:20494887-Bone Density, pubmed-meshheading:20494887-Case-Control Studies, pubmed-meshheading:20494887-Catalase, pubmed-meshheading:20494887-Energy Metabolism, pubmed-meshheading:20494887-Female, pubmed-meshheading:20494887-Femur, pubmed-meshheading:20494887-Gene Frequency, pubmed-meshheading:20494887-Glucose, pubmed-meshheading:20494887-Glucose Intolerance, pubmed-meshheading:20494887-Haplotypes, pubmed-meshheading:20494887-Homozygote, pubmed-meshheading:20494887-Humans, pubmed-meshheading:20494887-Hungary, pubmed-meshheading:20494887-Leptin, pubmed-meshheading:20494887-Male, pubmed-meshheading:20494887-Menopause, pubmed-meshheading:20494887-Middle Aged, pubmed-meshheading:20494887-Muscle, Skeletal, pubmed-meshheading:20494887-Osteocalcin, pubmed-meshheading:20494887-Polymorphism, Genetic, pubmed-meshheading:20494887-Sex Factors
pubmed:year
2010
pubmed:articleTitle
[Effects of catalase gene (RS769217) polymorphism on energy homeostasis and bone status are gender specific].
pubmed:affiliation
ANTSZ Veszprém DRC Kft. Balatonfüred Ady.
pubmed:publicationType
Journal Article, English Abstract