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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-6-4
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pubmed:abstractText |
A novel class of HA inhibitors (4a) was identified based on ligand similarity search of known HA inhibitors. Parallel synthesis and further structural modifications resulted in 1-phenyl-cyclopentanecarboxylic acid (4-cyano-phenyl)-methyl-amide 4t as a potent and selective inhibitor to phylogenetic H1 influenza viruses with an EC(50) of 98 nM against H1N1 A/Weiss/43 strain and over 1000-fold selectivity against host MDCK cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:ChenLiL,
pubmed-author:LiHaodongH,
pubmed-author:LiShaohuaS,
pubmed-author:LiWentaoW,
pubmed-author:LinXianfengX,
pubmed-author:QiuZongxingZ,
pubmed-author:TangGuozhiG,
pubmed-author:WangLishaL,
pubmed-author:WuJim ZJZ,
pubmed-author:YangWengangW,
pubmed-author:ZhuLeiL
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3507-10
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pubmed:meshHeading |
pubmed-meshheading:20494579-Animals,
pubmed-meshheading:20494579-Cell Line,
pubmed-meshheading:20494579-Cycloparaffins,
pubmed-meshheading:20494579-Dogs,
pubmed-meshheading:20494579-Drug Discovery,
pubmed-meshheading:20494579-Hemagglutinin Glycoproteins, Influenza Virus,
pubmed-meshheading:20494579-Humans,
pubmed-meshheading:20494579-Influenza, Human,
pubmed-meshheading:20494579-Influenza A Virus, H1N1 Subtype,
pubmed-meshheading:20494579-Structure-Activity Relationship,
pubmed-meshheading:20494579-Urea
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pubmed:year |
2010
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pubmed:articleTitle |
Discovery of novel 1-phenyl-cycloalkane carbamides as potent and selective influenza fusion inhibitors.
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pubmed:affiliation |
Roche R&D Center China, Shanghai, China. gordon.tang@roche.com
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pubmed:publicationType |
Journal Article
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