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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
2010-7-12
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pubmed:abstractText |
Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) and fluid wall shear stress have been reported to modulate the expression of genes related to inflammation, blood coagulation, thrombosis, and vascular constriction in cultured endothelial cells. In this study, we investigated the combined effect of laminar shear stress (LSS) and statins on endothelial cell gene expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1879-0631
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pubmed:author |
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pubmed:copyrightInfo |
Crown Copyright 2010. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
92-9
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pubmed:meshHeading |
pubmed-meshheading:20493886-Aorta, Abdominal,
pubmed-meshheading:20493886-Cells, Cultured,
pubmed-meshheading:20493886-Dose-Response Relationship, Drug,
pubmed-meshheading:20493886-Endothelium, Vascular,
pubmed-meshheading:20493886-Gene Expression Regulation,
pubmed-meshheading:20493886-Humans,
pubmed-meshheading:20493886-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:20493886-Kruppel-Like Transcription Factors,
pubmed-meshheading:20493886-Nitric Oxide Synthase Type III,
pubmed-meshheading:20493886-RNA, Messenger,
pubmed-meshheading:20493886-Simvastatin,
pubmed-meshheading:20493886-Stress, Mechanical,
pubmed-meshheading:20493886-Thrombomodulin
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pubmed:year |
2010
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pubmed:articleTitle |
Effect of simvastatin on Kruppel-like factor2, endothelial nitric oxide synthase and thrombomodulin expression in endothelial cells under shear stress.
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pubmed:affiliation |
Dept. of Chemical Engineering, McGill University, 3610 University Street, Montreal, QC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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