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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-6-4
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pubmed:abstractText |
We have designed and synthesized a novel series of alpha-amino cyclic boronates and incorporated them successfully in several acyclic templates at the P1 position. These compounds are inhibitors of the HCV NS3 serine protease, and structural studies show that they inhibit the NS3 protease by trapping the Ser-139 hydroxyl group in the active site. Synthetic methodologies and SARs of this series of compounds are described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BakerStephen JSJ,
pubmed-author:DingCharles ZCZ,
pubmed-author:EdgeColin MCM,
pubmed-author:EllisMalcolmM,
pubmed-author:FanDazhongD,
pubmed-author:GrimesRichard MRM,
pubmed-author:HubbardJulia AJA,
pubmed-author:JarvestRichard LRL,
pubmed-author:KazmierskiWieslaw MWM,
pubmed-author:LazaridesLinos XLX,
pubmed-author:LiQunQ,
pubmed-author:LiXianfengX,
pubmed-author:LiaoLiangL,
pubmed-author:McDowellBillB,
pubmed-author:MordauntJackie EJE,
pubmed-author:NassauPamelaP,
pubmed-author:NiZhi-JieZJ,
pubmed-author:PennicottLewis ELE,
pubmed-author:PlattnerJacob JJJ,
pubmed-author:QianXueleiX,
pubmed-author:RowlandPaulP,
pubmed-author:SkarzynskiTadeusz JTJ,
pubmed-author:SlaterMartin JMJ,
pubmed-author:SmithGary KGK,
pubmed-author:SomersDonD,
pubmed-author:ThommesPiaP,
pubmed-author:VoasRR,
pubmed-author:WhiteGemma VGV,
pubmed-author:WrightJonJ,
pubmed-author:WrightLois LLL,
pubmed-author:ZhangYong-KangYK,
pubmed-author:ZhouYasheenY,
pubmed-author:ZouWuxinW
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3550-6
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.
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pubmed:affiliation |
Anacor Pharmaceuticals, Inc., Palo Alto, CA 94303, USA. xli@anacor.com
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pubmed:publicationType |
Journal Article
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