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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1978-5-8
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pubmed:abstractText |
The concentrations of nicotinic drugs required to effect a 50% transfer of triphosphol[3H]isositide from an aqueous phase to a nonaqueous phase closely approximated their concentrations for both in vivo neuromuscular blocking activity and binding to purified nicotinic receptors, and correlated well (correlation coefficient = 0.95)) with their biological activities measured by other workers in an Electrophorus electroplax preparation. The triphospho[3H]inositide transfer induced by nicotinic ligands was dependent on the lipid concentration and was potentiated by Ca2+. The affinity constants of 45Ca2+ for triphosphoinositide were similar to those for the purified nicotinic receptor. These and other findings suggest the possibility that triphosphoinositide (phosphatidylinositol bisphosphate) is a binding site of the nicotinic receptor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-1068449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-1096798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-1250411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-127623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-13641241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-197208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-4302257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-4318456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-4334644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-5497197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/204933-5858631
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
784-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1978
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pubmed:articleTitle |
Alteration of the physicochemical properties of triphosphoinositide by nicotinic ligands.
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pubmed:publicationType |
Journal Article
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