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rdf:type |
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lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0014597,
umls-concept:C0017262,
umls-concept:C0024623,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0598086,
umls-concept:C0598388,
umls-concept:C1415887,
umls-concept:C1419040,
umls-concept:C1419772,
umls-concept:C1420433,
umls-concept:C1424666,
umls-concept:C1512554,
umls-concept:C1704242
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pubmed:issue |
4
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pubmed:dateCreated |
2010-5-24
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pubmed:abstractText |
Runx family transcription factors are integral components of transforming growth factor-beta signaling pathways and have been implicated in cell cycle regulation, differentiation, apoptosis, and malignant transformation. The silencing of tumor suppressor genes by aberrant hypermethylation occurs frequently in human cancer. It has been noted previously that Runx3 is regarded as an important tumor suppressor gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Azacitidine,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 3 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA (Cytosine-5-)-Methyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA...,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Runx3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/decitabine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1440-1746
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
823-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20492341-Adult,
pubmed-meshheading:20492341-Aged,
pubmed-meshheading:20492341-Apoptosis,
pubmed-meshheading:20492341-Azacitidine,
pubmed-meshheading:20492341-Blotting, Western,
pubmed-meshheading:20492341-Caspase 3,
pubmed-meshheading:20492341-Cell Cycle,
pubmed-meshheading:20492341-Cell Line, Tumor,
pubmed-meshheading:20492341-Cell Proliferation,
pubmed-meshheading:20492341-Core Binding Factor Alpha 3 Subunit,
pubmed-meshheading:20492341-CpG Islands,
pubmed-meshheading:20492341-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:20492341-DNA (Cytosine-5-)-Methyltransferase,
pubmed-meshheading:20492341-DNA Methylation,
pubmed-meshheading:20492341-Down-Regulation,
pubmed-meshheading:20492341-Enzyme Inhibitors,
pubmed-meshheading:20492341-Epithelial Cells,
pubmed-meshheading:20492341-Female,
pubmed-meshheading:20492341-Gastric Mucosa,
pubmed-meshheading:20492341-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20492341-Humans,
pubmed-meshheading:20492341-Immunohistochemistry,
pubmed-meshheading:20492341-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20492341-Male,
pubmed-meshheading:20492341-Middle Aged,
pubmed-meshheading:20492341-Neoplasm Staging,
pubmed-meshheading:20492341-Promoter Regions, Genetic,
pubmed-meshheading:20492341-RNA, Messenger,
pubmed-meshheading:20492341-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20492341-Stomach Neoplasms,
pubmed-meshheading:20492341-Time Factors,
pubmed-meshheading:20492341-Up-Regulation,
pubmed-meshheading:20492341-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer.
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pubmed:affiliation |
Department of Gastroenterology, First Affiliated Hospital of Soochow University, China. weichangchen@126.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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