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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-5-24
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pubmed:abstractText |
Yuzu (Citrus junos Tanaka) has been used as a traditional medicine in Japan. We investigated in vitro anti-inflammatory effects of limonene from yuzu peel on human eosinophilic leukemia HL-60 clone 15 cells. To examine anti-inflammatory effects of limonene on the cells, we measured the level of reactive oxygen species (ROS), monocyte chemoattractant protein-1 (MCP-1), nuclear factor (NF) kappa B, and p38 mitogen-activated protein kinase (MAPK). We found that low concentration of limonene (7.34 mmol/L) inhibited the production of ROS for eotaxin-stimulated HL-60 clone 15 cells. 14.68 mmol/L concentration of limonene diminished MCP-1 production via NF-kappa B activation comparable to the addition of the proteasomal inhibitor MG132. In addition, it inhibited cell chemotaxis in a p38 MAPK dependent manner similar to the adding of SB203580. These results suggest that limonene may have potential anti-inflammatory efficacy for the treatment of bronchial asthma by inhibiting cytokines, ROS production, and inactivating eosinophil migration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CCL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexenes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Oils, Volatile,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Terpenes,
http://linkedlifedata.com/resource/pubmed/chemical/limonene,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1750-3841
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
H87-92
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pubmed:meshHeading |
pubmed-meshheading:20492298-Anti-Inflammatory Agents,
pubmed-meshheading:20492298-Asthma,
pubmed-meshheading:20492298-Cell Movement,
pubmed-meshheading:20492298-Chemokine CCL2,
pubmed-meshheading:20492298-Citrus,
pubmed-meshheading:20492298-Cyclohexenes,
pubmed-meshheading:20492298-DNA-Binding Proteins,
pubmed-meshheading:20492298-Dose-Response Relationship, Drug,
pubmed-meshheading:20492298-Eosinophils,
pubmed-meshheading:20492298-Fruit,
pubmed-meshheading:20492298-HL-60 Cells,
pubmed-meshheading:20492298-Humans,
pubmed-meshheading:20492298-Japan,
pubmed-meshheading:20492298-Medicine, East Asian Traditional,
pubmed-meshheading:20492298-NF-kappa B,
pubmed-meshheading:20492298-Oils, Volatile,
pubmed-meshheading:20492298-Phosphorylation,
pubmed-meshheading:20492298-Reactive Oxygen Species,
pubmed-meshheading:20492298-Terpenes,
pubmed-meshheading:20492298-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils.
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pubmed:affiliation |
Dept. of Environmental Medicine, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi 783-8505, Japan. hirotar@kochi-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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