Linked Life Data

20490978

Source:http://linkedlifedata.com/resource/pubmed/id/20490978

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-5-21
pubmed:abstractText
Endothelial phenotypes display remarkable heterogeneity in structure and function, in time and space, and in health and disease. As a biological trait, phenotypic heterogeneity has evolutionary and proximate explanations. Here we introduce concepts of evolutionary biology, evolutionary developmental biology, developmental plasticity, and homeostasis toward understanding mechanisms of endothelial heterogeneity. We conclude that endothelial heterogeneity arises from a complex interplay between the genome and the environment, operating at both population and organismal levels across a broad spectrum of time. Mismatch between the genome and/or epigenome and the environment is an important determinant of human vascular disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1098-9064
pubmed:author
pubmed:copyrightInfo
Thieme Medical Publishers.
pubmed:issnType
Electronic
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
276-85
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Proximate and evolutionary causation of endothelial heterogeneity.
pubmed:affiliation
Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. waird@bidmc.harvard.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural