Linked Life Data

20490866

Source:http://linkedlifedata.com/resource/pubmed/id/20490866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-6-9
pubmed:abstractText
We aimed to design and manufacture a novel low-cost polyimide microelectrode array (MEA) chip for visual prosthesis research and to evaluate its biological features. A microelectrode array was developed, based on Flexible Printed Circuit Board (FPC) technology which enables electrical stimulation of the cortex. In an in vitro experiment, rat visual cortex cells were co-cultured with the chip and examined using scanning electron microscopy. Trypan blue exclusion and methyl blue tetrazolium tests showed that cell viability and survival rates (90-98%) did not significantly differ between the co-cultured chip group and the control group. In an in vivo experiment HE/Nissl staining performed to investigate the possibility of brain tissue degeneration around implanted MEAs showed no negative effects of the chip on visual cortical cells after 1 month in situ. The good functional characteristics and biocomptability suggest that such a low-cost device could have widespread application, particularly in countries with a large blind population and limited financial resources.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1432-0878
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
340
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
421-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The design and preparation of a flexible bio-chip for use as a visual prosthesis, and evaluation of its biological features.
pubmed:affiliation
Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies