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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-6-4
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pubmed:abstractText |
Head group analogues of the antibacterial and antiparasitic drug nitazoxanide (NTZ) are presented. A library of 39 analogues was synthesized and assayed for their ability to suppress growth of Helicobacter pylori, Campylobacter jejuni, Clostridium difficile and inhibit NTZ target pyruvate:ferredoxin oxidoreductase (PFOR). Two head groups assayed recapitulated NTZ activity and possessed improved activity over their 2-amino-5-nitrothiazole counterparts, demonstrating that head group modification is a viable route for the synthesis of NTZ-related antibacterial analogues.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-10984012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-11252111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-11854075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-12055813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-12069963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-15752617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-16495282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-17158936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-17229238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-17722965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-18971494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-19135998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-19438716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-19638339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-19736929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-20085998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-20086145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-5219700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-6277867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-8550425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20488706-9797212
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3537-9
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide.
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pubmed:affiliation |
Department of Chemistry, University of Virginia, Charlottesville, VA 22904-4319, USA. teb2m@virginia.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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