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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-6-4
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pubmed:abstractText |
A series of novel azobicyclo[3.3.0]octane derivatives were synthesized and evaluated as dipeptidyl peptidase 4 (DPP-4) inhibitors. The effort resulted in the discovery of inhibitor 2a, which exhibited excellent efficacies in an oral glucose tolerance test. Introduction of methyl group (2j) could prolong the inhibition of serum DPP-4 activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:ChoTang PengTP,
pubmed-author:FengJunJ,
pubmed-author:FengYingY,
pubmed-author:GangLin ZhiLZ,
pubmed-author:HongFu JianFJ,
pubmed-author:HongShe GaoSG,
pubmed-author:JingLuo JingLJ,
pubmed-author:JunLu HeLH,
pubmed-author:KeYan PangYP,
pubmed-author:LengYingY,
pubmed-author:LiangGuan DongGD,
pubmed-author:LongYang FangYF,
pubmed-author:ShenGong AiGA,
pubmed-author:TaiMong XianMX,
pubmed-author:WangDanD,
pubmed-author:WangLinL,
pubmed-author:WangYangY,
pubmed-author:YuanShen GuangSG,
pubmed-author:ZhangLeiL
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3565-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20488702-Animals,
pubmed-meshheading:20488702-Azo Compounds,
pubmed-meshheading:20488702-Bicyclo Compounds,
pubmed-meshheading:20488702-Diabetes Mellitus, Type 2,
pubmed-meshheading:20488702-Dipeptidyl Peptidase 4,
pubmed-meshheading:20488702-Dipeptidyl-Peptidase IV Inhibitors,
pubmed-meshheading:20488702-Glucose Tolerance Test,
pubmed-meshheading:20488702-Hypoglycemic Agents,
pubmed-meshheading:20488702-Mice,
pubmed-meshheading:20488702-Mice, Inbred ICR,
pubmed-meshheading:20488702-Octanes,
pubmed-meshheading:20488702-Pharmacokinetics,
pubmed-meshheading:20488702-Rats,
pubmed-meshheading:20488702-Rats, Sprague-Dawley,
pubmed-meshheading:20488702-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.
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pubmed:affiliation |
Shanghai Hengrui Pharmaceuticals Co., Ltd, Shanghai, China. tangpc@shhrp.com
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pubmed:publicationType |
Journal Article
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