Linked Life Data

20488698

Source:http://linkedlifedata.com/resource/pubmed/id/20488698

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2010-6-21
pubmed:abstractText
To evaluate the effects of dissolved oxygen (DO) control strategy on cell growth and the production of antibiotic (cyclo(2-Me-BABA-Gly)) by Xenorhabdus nematophila. The effects of different agitation speeds and DO concentrations on cell growth and antibiotic activity of X. nematophila YL001 were examined. Experiments showed that higher agitation speeds and DO concentrations at earlier fermentation stage were favorable for cell growth and antibiotic production. At mid- and later-stage, properly decreasing DO concentration can strengthen cell growth and antibiotic production. Based on the kinetic information about the effects of agitation speeds and DO concentrations on the fermentation, the two-stage DO control strategy in which DO concentration was controlled to 70% in the first 18 h, and then switched to 50% after 18 h, was established to improve the biomass and antibiotic activity. By applying this DO-shift strategy in X. nematophila YL001 fermentation, maximal antibiotic activity and biomass reached 252.0+/-6.10 U/mL and 30.04+/-2.50 g/L, respectively, thus was 18.99% and 15.36% more than in the cultures at constantly 50% DO.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1873-2976
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7529-36
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Effects of constant and shifting dissolved oxygen concentration on the growth and antibiotic activity of Xenorhabdus nematophila.
pubmed:affiliation
Research and Development Center of Biorational Pesticides, Northwest A & F University, Yangling Shaanxi, PR China. yhwang@nwsuaf.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't