Source:http://linkedlifedata.com/resource/pubmed/id/20488590
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2010-6-14
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| pubmed:abstractText |
A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide-hydrazone derivatives 3a-l were less active than pyrazinamide. In contrast, the N(4)-ethyl-N(1)-pyrazinoyl-thiosemicarbazide 4 showed the highest activity against M. tuberculosis H(37)Rv (IC(90) = 16.87 microg/mL). Details of the structure-activity and structure-cytotoxicity relationships are discussed.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1768-3254
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3384-8
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| pubmed:meshHeading |
pubmed-meshheading:20488590-Animals,
pubmed-meshheading:20488590-Anti-Bacterial Agents,
pubmed-meshheading:20488590-Cercopithecus aethiops,
pubmed-meshheading:20488590-Hydrazines,
pubmed-meshheading:20488590-Mycobacterium tuberculosis,
pubmed-meshheading:20488590-Pyrazines,
pubmed-meshheading:20488590-Structure-Activity Relationship,
pubmed-meshheading:20488590-Vero Cells
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| pubmed:year |
2010
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| pubmed:articleTitle |
Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives.
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| pubmed:affiliation |
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt. abulnil@hotmail.com
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| pubmed:publicationType |
Journal Article
|