Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2010-11-29
pubmed:abstractText
The T cell composition of the peritoneal cavity (PerC) in naïve BALB/c, C57BL/6, DBA/2J, and B-1 B cell-defective BALB.xid mice was investigated. The BALB.xid PerC T cell pool had a high CD4:CD8 T cell ratio relative to the other strains whose ratios were similar to those found in their lymph node and spleen. All mice had significant representation of T cells with an activated (CD25(+), GITR(hi), CD44(hi), CD45RB(lo), CD62L(lo)) phenotype and low numbers of Foxp3(+) T(reg) cells in their PerC. Despite a phenotype indicative of activation, peritoneal T cell responses to CD3 ligation were very low for C57BL/6 and BALB.xid, but not BALB/c, mice. Enzyme inhibition and cytokine neutralization studies revealed active suppression of the T cell response mediated by the macrophages that represent a significant portion of PerC leucocytes. Driven by IFN? to express iNOS, macrophages suppressed T cell activation in vitro by arginine catabolism. Although BALB/c T cells were also in a macrophage-dense environment their limited IFN? production failed to trigger suppression. This difference between BALB/c and BALB.xid PerC T cells suggests a role for xid in shaping macrophage-mediated immune regulation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1878-3279
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier GmbH. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
216
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
256-64
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:20488579-Animals, pubmed-meshheading:20488579-CD4-Positive T-Lymphocytes, pubmed-meshheading:20488579-CD8-Positive T-Lymphocytes, pubmed-meshheading:20488579-Cell Communication, pubmed-meshheading:20488579-Cells, Cultured, pubmed-meshheading:20488579-Forkhead Transcription Factors, pubmed-meshheading:20488579-Glucocorticoid-Induced TNFR-Related Protein, pubmed-meshheading:20488579-Immune Tolerance, pubmed-meshheading:20488579-Immunologic Memory, pubmed-meshheading:20488579-Interleukin-2 Receptor alpha Subunit, pubmed-meshheading:20488579-Macrophages, Peritoneal, pubmed-meshheading:20488579-Mice, pubmed-meshheading:20488579-Mice, Inbred Strains, pubmed-meshheading:20488579-Mice, Mutant Strains, pubmed-meshheading:20488579-Receptors, Nerve Growth Factor, pubmed-meshheading:20488579-Receptors, Tumor Necrosis Factor, pubmed-meshheading:20488579-T-Lymphocytes, Regulatory
pubmed:articleTitle
Peritoneal T lymphocyte regulation by macrophages.
pubmed:affiliation
Department of Biology, Rider University, Lawrenceville, NJ 08648-3099, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural