Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-12-20
pubmed:abstractText
We investigated the correlation between MDR1 promoter methylation status and MDR1 expression in 228 hematologic malignancies patients and 90 healthy controls. High level of MDR1 mRNA correlated to promoter hypomethylation and strongly associated with poor prognosis indicated by 2-year survival rates, poor CR rate (without BMT) and high relapse rate (with BMT). Furthermore, relative luciferase activity of methylated MDR1 at promoter -50 region was significantly higher than that of the unmethylated. In addition, MDR1 in K562 cells elevated significantly after 5-Aza-dC treatment. In summary, MDR1 promoter hypomethylation conferred its up-regulation and indicated poor prognosis in patients with and without BMT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1873-5835
pubmed:author
pubmed:copyrightInfo
Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-9
pubmed:meshHeading
pubmed-meshheading:20488541-Adolescent, pubmed-meshheading:20488541-Adult, pubmed-meshheading:20488541-Base Sequence, pubmed-meshheading:20488541-Bone Marrow Transplantation, pubmed-meshheading:20488541-Child, pubmed-meshheading:20488541-Child, Preschool, pubmed-meshheading:20488541-DNA Methylation, pubmed-meshheading:20488541-DNA Primers, pubmed-meshheading:20488541-Female, pubmed-meshheading:20488541-Flow Cytometry, pubmed-meshheading:20488541-Hematologic Neoplasms, pubmed-meshheading:20488541-Humans, pubmed-meshheading:20488541-Male, pubmed-meshheading:20488541-Middle Aged, pubmed-meshheading:20488541-P-Glycoprotein, pubmed-meshheading:20488541-Prognosis, pubmed-meshheading:20488541-Promoter Regions, Genetic, pubmed-meshheading:20488541-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:20488541-Up-Regulation, pubmed-meshheading:20488541-Young Adult
pubmed:year
2011
pubmed:articleTitle
Up-regulation of ABCB1/P-glycoprotein by escaping promoter hypermethylation indicates poor prognosis in hematologic malignancy patients with and without bone marrow transplantation.
pubmed:affiliation
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't