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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017337,
umls-concept:C0023418,
umls-concept:C0040648,
umls-concept:C0332281,
umls-concept:C0521432,
umls-concept:C0521447,
umls-concept:C0851285,
umls-concept:C1333663,
umls-concept:C1336789,
umls-concept:C1516960,
umls-concept:C1530719,
umls-concept:C1539715
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pubmed:dateCreated |
2010-6-9
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pubmed:abstractText |
The Eight-Twenty-One (ETO) nuclear co-repressor gene belongs to the ETO homologue family also containing Myeloid Translocation Gene on chromosome 16 (MTG16) and myeloid translocation Gene-Related protein 1 (MTGR1). By chromosomal translocations ETO and MTG16 become parts of fusion proteins characteristic of morphological variants of acute myeloid leukemia. Normal functions of ETO homologues have as yet not been examined. The goal of this work was to identify structural and functional promoter elements upstream of the coding sequence of the ETO gene in order to explore lineage-specific hematopoietic expression and get hints to function.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20487545-10216081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20487545-10688654,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20487545-9819405
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AML1-ETO fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/GATA1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1T1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2199
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20487545-Humans,
pubmed-meshheading:20487545-Animals,
pubmed-meshheading:20487545-Megakaryocytes,
pubmed-meshheading:20487545-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:20487545-Base Sequence,
pubmed-meshheading:20487545-Leukemia, Myeloid, Acute,
pubmed-meshheading:20487545-Molecular Sequence Data,
pubmed-meshheading:20487545-Cercopithecus aethiops
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