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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-10-28
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pubmed:abstractText |
Dendrimeric polyguanidilyated translocators (DPTs) are nanosized novel dendrimers that efficiently translocate molecules across biological barriers. The purpose of this study was to develop a DPT that could serve as an ophthalmic delivery vehicle for gatifloxacin and to evaluate its in vitro and in vivo delivery after topical application.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5804-16
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pubmed:meshHeading |
pubmed-meshheading:20484584-Administration, Topical,
pubmed-meshheading:20484584-Animals,
pubmed-meshheading:20484584-Anti-Infective Agents,
pubmed-meshheading:20484584-Area Under Curve,
pubmed-meshheading:20484584-Calorimetry,
pubmed-meshheading:20484584-Cattle,
pubmed-meshheading:20484584-Chromatography, High Pressure Liquid,
pubmed-meshheading:20484584-Dendrimers,
pubmed-meshheading:20484584-Drug Delivery Systems,
pubmed-meshheading:20484584-Drug Interactions,
pubmed-meshheading:20484584-Epithelium, Corneal,
pubmed-meshheading:20484584-Fluorescein-5-isothiocyanate,
pubmed-meshheading:20484584-Fluoroquinolones,
pubmed-meshheading:20484584-Humans,
pubmed-meshheading:20484584-Magnetic Resonance Spectroscopy,
pubmed-meshheading:20484584-Male,
pubmed-meshheading:20484584-Methicillin-Resistant Staphylococcus aureus,
pubmed-meshheading:20484584-Microbial Sensitivity Tests,
pubmed-meshheading:20484584-Microscopy, Confocal,
pubmed-meshheading:20484584-Nanoparticles,
pubmed-meshheading:20484584-Ophthalmic Solutions,
pubmed-meshheading:20484584-Permeability,
pubmed-meshheading:20484584-Poly G,
pubmed-meshheading:20484584-Rabbits,
pubmed-meshheading:20484584-Solubility,
pubmed-meshheading:20484584-Spectroscopy, Fourier Transform Infrared,
pubmed-meshheading:20484584-Tandem Mass Spectrometry,
pubmed-meshheading:20484584-Tissue Distribution
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pubmed:year |
2010
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pubmed:articleTitle |
Nanosized dendritic polyguanidilyated translocators for enhanced solubility, permeability, and delivery of gatifloxacin.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado 80045, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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