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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-10-28
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pubmed:abstractText |
Congenital stromal corneal dystrophy (CSCD) is characterized by stromal opacities that morphologically are seen as interlamellar layers of amorphous substance with small filaments, the nature of which has hitherto been unknown. CSCD is associated with truncating mutations in the decorin gene (DCN). To understand the molecular basis for the corneal opacities we analyzed the expression of decorin in this disease, both at the morphologic and the molecular level.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5578-82
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pubmed:meshHeading |
pubmed-meshheading:20484579-Blotting, Western,
pubmed-meshheading:20484579-Cells, Cultured,
pubmed-meshheading:20484579-Chromatography, Gel,
pubmed-meshheading:20484579-Corneal Dystrophies, Hereditary,
pubmed-meshheading:20484579-Corneal Opacity,
pubmed-meshheading:20484579-Corneal Stroma,
pubmed-meshheading:20484579-Decorin,
pubmed-meshheading:20484579-Fibroblasts,
pubmed-meshheading:20484579-Gene Expression,
pubmed-meshheading:20484579-Humans,
pubmed-meshheading:20484579-Immunoblotting,
pubmed-meshheading:20484579-Indoles,
pubmed-meshheading:20484579-Kidney,
pubmed-meshheading:20484579-Microscopy, Immunoelectron,
pubmed-meshheading:20484579-Organometallic Compounds,
pubmed-meshheading:20484579-Plasmids,
pubmed-meshheading:20484579-RNA, Messenger,
pubmed-meshheading:20484579-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20484579-Staining and Labeling,
pubmed-meshheading:20484579-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Decorin accumulation contributes to the stromal opacities found in congenital stromal corneal dystrophy.
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pubmed:affiliation |
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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