Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-6-2
pubmed:abstractText
Cancer cells commonly have a high rate of telomere loss, even when expressing telomerase, contributing to chromosome instability and tumor cell progression. This review addresses the hypothesis that this high rate of telomere loss results from a combination of four factors. The first factor is an increase in the frequency of double-strand breaks (DSB) at fragile sites in cancer cells due to replication stress. The second factor is that telomeres are fragile sites. The third factor is that subtelomeric regions are highly sensitive to DSBs, so that DSBs near telomeres have an increased probability of resulting in chromosome instability. The fourth factor is that cancer cells may be deficient in chromosome healing, the de novo addition of telomeres to the sites of DSBs, a mechanism that prevents chromosome instability resulting from DSBs near telomeres. Understanding these factors and how they influence telomere loss will provide important insights into the mechanisms of chromosome instability and the development of novel approaches for anti-cancer therapy. Cancer Res; 70(11); 4255-9. (c)2010 AACR.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-10359789, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-10924407, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-10926538, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-11228547, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-11675499, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-12052890, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-12142527, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-12407447, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-12729759, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-12788566, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-15065663, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-15387140, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-15798094, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-15935739, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-16784900, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-17237781, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-17296333, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-17687332, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-18079179, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-18084328, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-18502190, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-18584027, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-18594563, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-18680434, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-19442252, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-19540174, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-19596237, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-19654615, http://linkedlifedata.com/resource/pubmed/commentcorrection/20484032-19838171
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1538-7445
pubmed:author
pubmed:copyrightInfo
Copyright 2010 AACR.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4255-9
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Telomere loss as a mechanism for chromosome instability in human cancer.
pubmed:affiliation
Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143-1331, USA. jmurnane@radonc.ucsf.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural