rdf:type |
|
lifeskim:mentions |
umls-concept:C0032000,
umls-concept:C0035820,
umls-concept:C0208804,
umls-concept:C0220825,
umls-concept:C0220901,
umls-concept:C0282443,
umls-concept:C0812425,
umls-concept:C1511545,
umls-concept:C1552617,
umls-concept:C1704970,
umls-concept:C2698830
|
pubmed:issue |
10
|
pubmed:dateCreated |
2010-10-20
|
pubmed:abstractText |
The present article presents an overview of the literature, and analyses the methods and the primary questions related to assessment of proliferation index using the Ki-67/MIB-1 labeling index in pituitary adenomas. Although atypical adenomas are characterized by their atypical morphological features by an elevated mitotic index, a Ki-67 (MIB-1) labeling index greater than 3% and extensive nuclear staining for p53, use of the proliferation index (LI) of pituitary adenomas in assessing the degree of tumor aggressiveness is a controversial topic in the literature, and there are disparate results involving many studies.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
1743-1328
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
32
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1060-71
|
pubmed:meshHeading |
pubmed-meshheading:20483025-Adenoma,
pubmed-meshheading:20483025-Antibodies, Antinuclear,
pubmed-meshheading:20483025-Antibodies, Monoclonal,
pubmed-meshheading:20483025-Cell Proliferation,
pubmed-meshheading:20483025-Humans,
pubmed-meshheading:20483025-Ki-67 Antigen,
pubmed-meshheading:20483025-Mitotic Index,
pubmed-meshheading:20483025-Neoplasm Invasiveness,
pubmed-meshheading:20483025-Neoplasm Recurrence, Local,
pubmed-meshheading:20483025-Pituitary Neoplasms,
pubmed-meshheading:20483025-Prognosis,
pubmed-meshheading:20483025-Tumor Markers, Biological
|
pubmed:year |
2010
|
pubmed:articleTitle |
Labeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical review.
|
pubmed:affiliation |
Department of Neurology, São Paulo Medical School, State University of São Paulo, Brazil. phpaneurocir@gmail.com
|
pubmed:publicationType |
Journal Article,
Review
|