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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-6-15
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pubmed:abstractText |
Klotho was originally characterized as an anti-aging gene that predisposed Klotho-deficient mice to a premature aging-like syndrome. Recently, KLOTHO was reported to function as a secreted Wnt antagonist and as a tumor suppressor. Epigenetic gene silencing of secreted Wnt antagonists is considered a common event in a wide range of human malignancies. Abnormal activation of the canonical Wnt pathway due to epigenetic deregulation of Wnt antagonists is thought to play a crucial role in cervical tumorigenesis. In this study, we examined epigenetic silencing of KLOTHO in human cervical carcinoma.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20482749-11520139,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
pubmed-author:BaeDong HanDH,
pubmed-author:ChangBoogiB,
pubmed-author:HanYoungsooY,
pubmed-author:JeonSeobS,
pubmed-author:JeongDong-JunDJ,
pubmed-author:JungSam-IlSI,
pubmed-author:KimChang-JinCJ,
pubmed-author:KimJinsunJ,
pubmed-author:KimKeun IlKI,
pubmed-author:LeeJaehyoukJ,
pubmed-author:LeeMyeong-SokMS,
pubmed-author:LeeSoonduckS,
pubmed-author:LimJong-SeokJS,
pubmed-author:ParkJin-HwaJH,
pubmed-author:YangInchulI,
pubmed-author:YangYoungY,
pubmed-author:YiLishaL
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20482749-Chromatin Immunoprecipitation,
pubmed-meshheading:20482749-CpG Islands,
pubmed-meshheading:20482749-DNA Methylation,
pubmed-meshheading:20482749-Female,
pubmed-meshheading:20482749-Gene Expression,
pubmed-meshheading:20482749-Gene Expression Profiling,
pubmed-meshheading:20482749-Gene Silencing,
pubmed-meshheading:20482749-Glucuronidase,
pubmed-meshheading:20482749-Humans,
pubmed-meshheading:20482749-Immunoblotting,
pubmed-meshheading:20482749-Promoter Regions, Genetic,
pubmed-meshheading:20482749-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20482749-Transfection,
pubmed-meshheading:20482749-Uterine Cervical Neoplasms,
pubmed-meshheading:20482749-Wnt Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma.
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pubmed:affiliation |
Research Center for Women's Diseases and Division of Biological Science, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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