Linked Life Data

20482371

Source:http://linkedlifedata.com/resource/pubmed/id/20482371

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-6-3
pubmed:abstractText
As the global community evaluates the unprecedented investment in the scale-up of human immunodeficiency virus (HIV) therapy and considers future investments in HIV care, it is crucial to identify those HIV interventions that maximize the benefit realized from each dollar spent. The use of laboratory monitoring assays--CD4 cell count and HIV RNA level--in decisions about when to initiate and switch antiretroviral therapy may offer substantial clinical benefit, but their economic value remains controversial. Cost-effectiveness analysis can be used to evaluate the value for money of strategies for HIV care, including alternative approaches to laboratory monitoring. Five published cost-effectiveness analyses address the question of CD4 cell count and HIV RNA level monitoring for HIV-infected patients in Africa, with differing conclusions. We describe the use of cost-effectiveness analysis in resource-limited settings and review the cost-effectiveness literature with regard to monitoring the CD4 cell count and HIV RNA level in Africa, highlighting some of the most critical issues in this debate.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-16753490, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-16810113, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-16878233, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-16971720, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-17545710, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-17621241, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-18440426, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-18657699, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-18809819, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-19261189, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-19620143, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-20004464, http://linkedlifedata.com/resource/pubmed/commentcorrection/20482371-7934713
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1537-6591
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-92
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Cost-effectiveness of laboratory monitoring in sub-Saharan Africa: a review of the current literature.
pubmed:affiliation
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. rwalensky@partners.org
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural