20482321

Source:http://linkedlifedata.com/resource/pubmed/id/20482321

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0040649, umls-concept:C0851285, umls-concept:C1450477, umls-concept:C1521991
pubmed:issue	7
pubmed:dateCreated	2010-7-13
pubmed:abstractText	Ten years after the determination of the RNA polymerase II structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural biology, biochemistry, functional genomics, and computational methods. In this article, the efforts of our laboratory to move from an integrated structural biology of gene transcription towards molecular systems biology of gene regulation are reviewed.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9700112
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1437-4315
pubmed:author	pubmed-author:CramerPatrickP
pubmed:issnType	Electronic
pubmed:volume	391
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	731-5
pubmed:meshHeading	pubmed-meshheading:20482321-Gene Expression Regulation, pubmed-meshheading:20482321-Models, Molecular, pubmed-meshheading:20482321-Systems Biology, pubmed-meshheading:20482321-Transcription, Genetic
pubmed:year	2010
pubmed:articleTitle	Towards molecular systems biology of gene transcription and regulation.
pubmed:affiliation	Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig Maximilians University, Gene Center, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany. cramer@LMB.uni-muenchen.de
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't