Linked Life Data

20480816

Source:http://linkedlifedata.com/resource/pubmed/id/20480816

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-5-19
pubmed:abstractText
The authors presented a comparative study of polymorphous loci Ile105Val and Ala114Val in GSTP1 gene, C609T and C464T in NQO1 gene, Pro197Leu in GPX1 gene of workers engaged into ethylbenzene-styrene (JSC "Salavatnefteorgsintez") and of apparently healthy individuals without occupational exposure to toxic chemicals. The same polymorphous markers were studied in workers differentiated according to health state. Occurrence of genotypes Ile/ Val of GSTP1 gene, Pro/Leu in GPX1 gene in the main group were lower vs. that in the reference one. Occurrence of CC genotype of polymorphous locus of C609T in NQO1 gene in the examinees exceeded that in the reference group. Distribution analysis of haplotypes of NQO1 and GSTP1 revealed high occurrence of *A haplotype of GSTP1 gene and low occurrence of *B haplotype in the main group vs. the reference one. The authors proved that molecular genetic marker of toxic liver affection is a heterozygous genotype of Pro/Leu in GPX1 gene and a combination of II/PL/CC genotypes of polymorphous markers Ile105Val in GSTP1 gene, C609T in NQO1 gene, Pro197Leu in GPX1 gene.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1026-9428
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-24
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
[Role of polymorphic markers of antioxidants (NQO1, GSTP1, GPX1) genes in adaptive response to hazardous work conditions in workers].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract