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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-10-20
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pubmed:abstractText |
The amyloid-? peptide (A?) plays a central role in the mechanism of Alzheimer's disease, being the main constituent of the plaque deposits found in AD brains. A? amyloid formation and deposition are due to a conformational switching to a ?-enriched secondary structure. Our strategy to inhibit A? aggregation involves the re-conversion of A? conformation by adsorption to nanoparticles. NPs were synthesized by sulfonation and sulfation of polystyrene, leading to microgels and latexes. Both polymeric nanostructures affect the conformation of A? inducing an unordered state. Oligomerization was delayed and cytotoxicity reduced. The proper balance between hydrophilic moieties and hydrophobic chains seems to be an essential feature of effective NPs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1616-5195
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1152-63
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pubmed:meshHeading |
pubmed-meshheading:20480510-Alzheimer Disease,
pubmed-meshheading:20480510-Amyloid beta-Peptides,
pubmed-meshheading:20480510-Amyloid beta-Protein Precursor,
pubmed-meshheading:20480510-Animals,
pubmed-meshheading:20480510-Cell Death,
pubmed-meshheading:20480510-Cell Line, Tumor,
pubmed-meshheading:20480510-Gels,
pubmed-meshheading:20480510-Humans,
pubmed-meshheading:20480510-Nanoparticles,
pubmed-meshheading:20480510-Peptide Fragments,
pubmed-meshheading:20480510-Protein Conformation,
pubmed-meshheading:20480510-Surface-Active Agents
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pubmed:year |
2010
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pubmed:articleTitle |
Randomization of amyloid-?-peptide(1-42) conformation by sulfonated and sulfated nanoparticles reduces aggregation and cytotoxicity.
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pubmed:affiliation |
Max Planck Institute of Colloids and Interfaces, Wissenschaftspark Golm, Potsdam, Germany. saraiva@mpikg.mpg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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