Source:http://linkedlifedata.com/resource/pubmed/id/20479795
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2010-5-18
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pubmed:abstractText |
Recently developed optical-resolution photoacoustic microscopy (OR-PAM), which is based on the detection of optical absorption contrast, is complementary to other optical microscopy modalities such as optical confocal microscopy, optical coherence tomography, and multiphoton microscopy. A hybrid optical-mechanical scanning configuration increases the imaging speed of OR-PAM significantly, facilitating many demanding biomedical applications. With a high-pulse-repetition-rate laser, the hybrid-scanning OR-PAM can acquire one-dimensional depth-resolved images (A-lines) at 5 kHz and two-dimensional B-scan images containing 800 A-lines at 6.25 Hz. We demonstrated in vivo in a mouse three-dimensional imaging of the iris vasculature in 128 s for an 800x800x200 data set and of the ear vasculature in 256 s for an 800x1600x200 data set.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/5P60DK02057933,
http://linkedlifedata.com/resource/pubmed/grant/EB000712A2S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA113453901,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA134539-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA134539-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA134539-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB000712,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB000712-06A2S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB000712-07,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB000712-07S2,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB00071207S2,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB008085,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB008085-02,
http://linkedlifedata.com/resource/pubmed/grant/U54 CA136398,
http://linkedlifedata.com/resource/pubmed/grant/U54 CA136398-02
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1539-4794
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1521-3
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pubmed:dateRevised |
2011-1-12
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pubmed:meshHeading | |
pubmed:year |
2010
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pubmed:articleTitle |
Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging.
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pubmed:affiliation |
Department of Biomedical Engineering, Optical Imaging Lab, Washington University in St. Louis, Campus Box 1097,One Brookings Drive, St. Louis, Missouri 63130-4899, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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