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rdf:type |
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lifeskim:mentions |
umls-concept:C0021966,
umls-concept:C0033684,
umls-concept:C0035647,
umls-concept:C0037473,
umls-concept:C0040132,
umls-concept:C0085080,
umls-concept:C0086418,
umls-concept:C0243077,
umls-concept:C0243144,
umls-concept:C0598849,
umls-concept:C2603343
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pubmed:issue |
3
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pubmed:dateCreated |
2011-5-2
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pubmed:abstractText |
Thyroid gland is highly dependent on dietary intake of iodine for normal function, so it is particularly subjected to "endocrine disruptor" action. The human sodium/iodide symporter (hNIS) is an integral plasma membrane glycoprotein mediating the active transport of iodide into thyroid follicular cells, a crucial step for thyroid hormone biosynthesis. Beyond to perchlorate and thyocianate ions a few other inhibitors of iodide uptake have been described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/14-alpha Demethylase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Amphotericin B,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Allergic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Biotin,
http://linkedlifedata.com/resource/pubmed/chemical/Buspirone,
http://linkedlifedata.com/resource/pubmed/chemical/Econazole,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Iodides,
http://linkedlifedata.com/resource/pubmed/chemical/Metronidazole,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Papaverine,
http://linkedlifedata.com/resource/pubmed/chemical/Perchloric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Promethazine,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfadiazine,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/Thiocyanates,
http://linkedlifedata.com/resource/pubmed/chemical/perchlorate,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-iodide symporter
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1720-8386
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
170-4
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pubmed:meshHeading |
pubmed-meshheading:20479570-14-alpha Demethylase Inhibitors,
pubmed-meshheading:20479570-Amphotericin B,
pubmed-meshheading:20479570-Animals,
pubmed-meshheading:20479570-Anti-Allergic Agents,
pubmed-meshheading:20479570-Anti-Infective Agents,
pubmed-meshheading:20479570-Anti-Inflammatory Agents,
pubmed-meshheading:20479570-Atropine,
pubmed-meshheading:20479570-Biotin,
pubmed-meshheading:20479570-Buspirone,
pubmed-meshheading:20479570-CHO Cells,
pubmed-meshheading:20479570-Cricetinae,
pubmed-meshheading:20479570-Cricetulus,
pubmed-meshheading:20479570-Econazole,
pubmed-meshheading:20479570-Humans,
pubmed-meshheading:20479570-Hydrocortisone,
pubmed-meshheading:20479570-Iodides,
pubmed-meshheading:20479570-Metronidazole,
pubmed-meshheading:20479570-Muscarinic Antagonists,
pubmed-meshheading:20479570-Papaverine,
pubmed-meshheading:20479570-Perchloric Acid,
pubmed-meshheading:20479570-Phosphodiesterase Inhibitors,
pubmed-meshheading:20479570-Promethazine,
pubmed-meshheading:20479570-Serotonin Receptor Agonists,
pubmed-meshheading:20479570-Sulfadiazine,
pubmed-meshheading:20479570-Symporters,
pubmed-meshheading:20479570-Thiocyanates,
pubmed-meshheading:20479570-Thyroid Gland
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pubmed:year |
2011
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pubmed:articleTitle |
Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein.
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pubmed:affiliation |
Department of Endocrinology and Metabolism, Centro Eccellenza AmbiSEN, University of Pisa, Pisa, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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