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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2010-6-2
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pubmed:abstractText |
Reactive oxygen species have been implicated in the pathogenesis of ischemia/reperfusion (IR) injury. Recent studies suggest that NADPH oxidase may be a source of ROS during IR. Using an in vivo model of endothelial IR injury in the arm, we compared the response to IR in healthy volunteers with that in patients with chronic granulomatous disease. These patients have a molecular lesion in a subunit of NADPH oxidase that renders the enzyme inactive.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2310-6
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pubmed:meshHeading |
pubmed-meshheading:20479156-Adolescent,
pubmed-meshheading:20479156-Adult,
pubmed-meshheading:20479156-Blood Pressure,
pubmed-meshheading:20479156-Brachial Artery,
pubmed-meshheading:20479156-Case-Control Studies,
pubmed-meshheading:20479156-Endothelium, Vascular,
pubmed-meshheading:20479156-Female,
pubmed-meshheading:20479156-Granulomatous Disease, Chronic,
pubmed-meshheading:20479156-Humans,
pubmed-meshheading:20479156-Male,
pubmed-meshheading:20479156-Membrane Glycoproteins,
pubmed-meshheading:20479156-Middle Aged,
pubmed-meshheading:20479156-Models, Biological,
pubmed-meshheading:20479156-NADPH Oxidase,
pubmed-meshheading:20479156-Reactive Oxygen Species,
pubmed-meshheading:20479156-Reperfusion Injury,
pubmed-meshheading:20479156-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humans.
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pubmed:affiliation |
Institute of Child Health, University College London, UK. s.loukogeorgakis@ich.ucl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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