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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-7-12
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pubmed:abstractText |
Research into the biological processes that increase susceptibility to methamphetamine dependence has been conducted primarily in Asian populations. Using a case-control design this study's purpose was to explore, among a population of methamphetamine-dependent Caucasians, six putative single nucleotide polymorphisms previously found to be associated with methamphetamine dependence in Asian populations. A total of 193 non-psychotic males (117 methamphetamine-dependent and 76 controls) were genotyped for variants located in six genes (AKT1, ARRB2, BDNF, COMT, GSTP1, OPRM1). Genotypic and allelic frequencies, odds ratios, and 95% confidence intervals were calculated. None of the putative gene associations was significantly replicated in our sample of Caucasian men. Effect size comparisons suggest a trend toward allelic divergence for arrestin beta 2 (ARRB2) and glutathione S-transferase P1 (GSTP1) and allelic convergence for brain-derived neurotrophic factor (BDNF). Results provide preliminary support for further exploration and validation of candidate single nucleotide polymorphisms (SNPs) for methamphetamine (METH) dependence reported among Asian populations across other ethnic/ancestral groups.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-11300226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-12668357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-14751002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-15982448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-16109452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-16255080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-16476706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-18316681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-18368603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-8886164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20478633-9819064
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0165-1781
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
295-8
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pubmed:dateRevised |
2011-8-2
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pubmed:meshHeading |
pubmed-meshheading:20478633-Adult,
pubmed-meshheading:20478633-Amphetamine-Related Disorders,
pubmed-meshheading:20478633-Arrestins,
pubmed-meshheading:20478633-Asian Continental Ancestry Group,
pubmed-meshheading:20478633-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:20478633-Case-Control Studies,
pubmed-meshheading:20478633-Confidence Intervals,
pubmed-meshheading:20478633-Ethnic Groups,
pubmed-meshheading:20478633-European Continental Ancestry Group,
pubmed-meshheading:20478633-Gene Frequency,
pubmed-meshheading:20478633-Genetic Association Studies,
pubmed-meshheading:20478633-Genetic Predisposition to Disease,
pubmed-meshheading:20478633-Genotype,
pubmed-meshheading:20478633-Glutathione S-Transferase pi,
pubmed-meshheading:20478633-Humans,
pubmed-meshheading:20478633-Male,
pubmed-meshheading:20478633-Methamphetamine,
pubmed-meshheading:20478633-Middle Aged,
pubmed-meshheading:20478633-Odds Ratio,
pubmed-meshheading:20478633-Polymorphism, Single Nucleotide
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pubmed:year |
2010
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pubmed:articleTitle |
Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence.
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pubmed:affiliation |
Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA. cbousman@ucsd.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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