Linked Life Data

20478304

Source:http://linkedlifedata.com/resource/pubmed/id/20478304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2010-7-26
pubmed:abstractText
Plexins serve as receptors for semaphorins and play important roles in the developing nervous system. Plexin-B2 controls decisive developmental programs in the neural tube and cerebellum. However, whether Plexin-B2 also regulates biological functions in adult nonneuronal tissues is unknown. Here we show by two methodologically independent approaches that Plexin-B2 is expressed in discrete cell types of several nonneuronal tissues in the adult mouse. In the vasculature, Plexin-B2 is selectively expressed in functionally specialized endothelial cells. In endocrine organs, Plexin-B2 localizes to the pancreatic islets of Langerhans and to both cortex and medulla of the adrenal gland. Plexin-B2 expression is also detected in certain types of immune and epithelial cells. In addition, we report on a systematic comparison of the expression patterns of Plexin-B2 and its ligand Sema4C, which show complementarity or overlap in some but not all tissues. Furthermore, we demonstrate that Plexin-B2 and its family member Plexin-B1 display largely nonredundant expression patterns. This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1090-2422
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
316
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2477-86
pubmed:meshHeading
pubmed-meshheading:20478304-Animals, pubmed-meshheading:20478304-Blood Vessels, pubmed-meshheading:20478304-Embryo, Mammalian, pubmed-meshheading:20478304-Endocrine System, pubmed-meshheading:20478304-Gene Expression Profiling, pubmed-meshheading:20478304-Gene Expression Regulation, Developmental, pubmed-meshheading:20478304-Genes, Reporter, pubmed-meshheading:20478304-Ligands, pubmed-meshheading:20478304-Mice, pubmed-meshheading:20478304-Mice, Transgenic, pubmed-meshheading:20478304-Neovascularization, Physiologic, pubmed-meshheading:20478304-Nerve Tissue Proteins, pubmed-meshheading:20478304-Promoter Regions, Genetic, pubmed-meshheading:20478304-Receptors, Cell Surface, pubmed-meshheading:20478304-Respiratory System, pubmed-meshheading:20478304-Semaphorins, pubmed-meshheading:20478304-beta-Galactosidase
pubmed:year
2010
pubmed:articleTitle
A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.
pubmed:affiliation
Max-Planck-Institute for Heart and Lung Research, Department of Pharmacology, Ludwigstr. 43, 61231 Bad Nauheim, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't