Linked Life Data

2047577

Source:http://linkedlifedata.com/resource/pubmed/id/2047577

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-7-18
pubmed:abstractText
We evaluated the effect of dexamethasone on the synthesis of fibronectin by rat lung fibroblasts. A dose dependent inhibition was observed in fibroblasts isolated from normal lungs and in fibroblasts isolated early (4 days) and late (14 days) after the administration of endobronchial paraquat, and was more pronounced in fibroblasts exposed to dexamethasone for longer durations of time. Fibroblasts isolated early were more responsive to the inhibitory effects of dexamethasone on fibronectin synthesis. In addition, the distribution of fibronectin between the cellular and the extracellular compartments in these cells was altered. We conclude that fibroblasts of repairing lungs undergo changes in their responsiveness to corticosteroids during the repair process and are more susceptible to such therapeutic agents during the acute phase of injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-80
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Steroid responsiveness of fibroblasts of paraquat injured lungs.
pubmed:affiliation
Pulmonary Section, VAMC, Allen Park, MI.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't