| pubmed-article:20473534 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20473534 | lifeskim:mentions | umls-concept:C0018155 | lld:lifeskim |
| pubmed-article:20473534 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:20473534 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20473534 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20473534 | lifeskim:mentions | umls-concept:C0304231 | lld:lifeskim |
| pubmed-article:20473534 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20473534 | pubmed:dateCreated | 2010-10-26 | lld:pubmed |
| pubmed-article:20473534 | pubmed:abstractText | Anti-bacterial drug resistance is one of the most critical concerns among the scientist worldwide. The novel antimicrobial decapeptide SD-8 is designed and its minimal inhibitory concentration and therapeutic index (TI) was found in the range of 1-8 ?g/ml and 45-360, respectively, against major group of Gram positive pathogens (GPP). The peptide was also found to be least hemolytic at a concentration of 180 ?g/ml, i.e., nearly 77 times higher than its average effective concentration. The kinetics assay showed that the killing time is 120 min for methicillin-sensitive Staphylococcus aureus (MSSA) and 90 min for methicillin-resistant S. aureus (MRSA). Membrane permeabilization is the cause of peptide antimicrobial activity as shown by the transmission electron microscopy studies. The peptide showed the anti-inflammatory property by inhibiting COX-2 with a KD and Ki values of 2.36×10(-9) and 4.8×10(-8) M, respectively. The peptide was also found to be effective in vivo as derived from histopathological observations in a Staphylococcal skin infection rat model with MRSA as causative organism. | lld:pubmed |
| pubmed-article:20473534 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20473534 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473534 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20473534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473534 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20473534 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20473534 | pubmed:issn | 1438-2199 | lld:pubmed |
| pubmed-article:20473534 | pubmed:author | pubmed-author:ChaudhryRamaR | lld:pubmed |
| pubmed-article:20473534 | pubmed:author | pubmed-author:DeySharmistha... | lld:pubmed |
| pubmed-article:20473534 | pubmed:author | pubmed-author:SinghAbhay... | lld:pubmed |
| pubmed-article:20473534 | pubmed:author | pubmed-author:MishraBiswaji... | lld:pubmed |
| pubmed-article:20473534 | pubmed:author | pubmed-author:SomvanshiRish... | lld:pubmed |
| pubmed-article:20473534 | pubmed:author | pubmed-author:SrivastavaVip... | lld:pubmed |
| pubmed-article:20473534 | pubmed:author | pubmed-author:GillKamaldeep... | lld:pubmed |
| pubmed-article:20473534 | pubmed:author | pubmed-author:SomvanshiRame... | lld:pubmed |
| pubmed-article:20473534 | pubmed:author | pubmed-author:PatroIshan... | lld:pubmed |
| pubmed-article:20473534 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20473534 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:20473534 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20473534 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20473534 | pubmed:pagination | 1493-505 | lld:pubmed |
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| pubmed-article:20473534 | pubmed:meshHeading | pubmed-meshheading:20473534... | lld:pubmed |
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| pubmed-article:20473534 | pubmed:meshHeading | pubmed-meshheading:20473534... | lld:pubmed |
| pubmed-article:20473534 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20473534 | pubmed:articleTitle | SD-8, a novel therapeutic agent active against multidrug-resistant Gram positive cocci. | lld:pubmed |
| pubmed-article:20473534 | pubmed:affiliation | Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. | lld:pubmed |
| pubmed-article:20473534 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20473534 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
