|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2010-6-4
|
|
pubmed:abstractText |
Biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes have been synthesized and tested for their affinity toward alpha7 neuronal nicotinic receptors (NNRs). SAR studies established that 5-N-methyl substituent, heteroaryl linker and the nature of terminal aryl group are critical for the ligand to achieve potent alpha7 NNR agonist activity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
pubmed-author:AndersonDavid JDJ,
pubmed-author:BunnelleWilliam HWH,
pubmed-author:GopalakrishnanMuraliM,
pubmed-author:GrønlienJens HJH,
pubmed-author:HåkerudMonikaM,
pubmed-author:HelfrichRosalindR,
pubmed-author:JiJianguoJ,
pubmed-author:MalyszJohnJ,
pubmed-author:PetersDanD,
pubmed-author:RytherKeith BKB,
pubmed-author:SchrimpfMichael RMR,
pubmed-author:TaoLiL
|
|
pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3636-9
|
|
pubmed:meshHeading |
pubmed-meshheading:20472430-Animals,
pubmed-meshheading:20472430-Heptanes,
pubmed-meshheading:20472430-Humans,
pubmed-meshheading:20472430-Ligands,
pubmed-meshheading:20472430-Neurons,
pubmed-meshheading:20472430-Nicotinic Agonists,
pubmed-meshheading:20472430-Protein Binding,
pubmed-meshheading:20472430-Radioligand Assay,
pubmed-meshheading:20472430-Rats,
pubmed-meshheading:20472430-Receptors, Nicotinic,
pubmed-meshheading:20472430-Structure-Activity Relationship
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands.
|
|
pubmed:affiliation |
Neuroscience Research, GPRD, Abbott, Abbott Park, IL 60064-6117, USA. Tao.Li@abbott.com
|
|
pubmed:publicationType |
Journal Article
|
