Linked Life Data

20471377

Source:http://linkedlifedata.com/resource/pubmed/id/20471377

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-7-8
pubmed:abstractText
It has been confirmed that sleep has a key role in learning and memory. Our previous study indicated that paradoxical sleep deprivation (PSD) impairs spatial learning ability of rats, and the decrease in membrane excitability of CA1 pyramidal neurons contributes to deficits in performing a spatial learning task. To investigate the further ionic mechanisms, the persistent sodium currents (I(NaP)), the hyperpolarization-activated cation current (I(h)), and their roles in neuron excitability were detected. PSD decreased I(NaP) and suppressed spike ADP, which leads to the reduction of neuron excitability and to the increase of firing accommodation. In addition, PSD reduced the I(h) amplitude and the rebound excitability of CA1 pyramidal neurons. The results of the present study suggested that I(h) and I(NaP) contributed to the inhibitory effect of PSD on neuron excitability, further influencing learning and memory processing. Modulating the ion channels and increasing the membrane excitability of hippocampal neurons are possible targets for preventing the effects of paradoxical sleep deprivation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1872-6240
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
9
pubmed:volume
1343
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-42
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Ionic mechanisms of the effects of sleep deprivation on excitability in hippocampal pyramidal neurons.
pubmed:affiliation
Department of Nutrition and Food Hygiene, the Fourth Military Medical University, Xi'an 710032, PR China. fmmur.young@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't