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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-6-15
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pubmed:abstractText |
DNA replication is a fundamental biological process during S phase of cell division. It is initiated from several hundreds of origins along whole chromosome with different firing efficiencies (or frequency of usage). Direct measurement of origin firing efficiency by techniques such as DNA combing are time-consuming and lack the ability to measure all origins. Recent genome-wide study of DNA replication approximated origin firing efficiency by indirectly measuring other quantities related to replication. However, these approximation methods do not reflect properties of origin firing and may lead to inappropriate estimations.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-10500092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-11588253,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-14566325,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-16429127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-1683846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-16847347,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-17636020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-17684567,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-18079179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-18093330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-1809350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-18713859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-2018976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-2685553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-9380711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-9491800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20462459-9491801
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247
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pubmed:meshHeading |
pubmed-meshheading:20462459-DNA Copy Number Variations,
pubmed-meshheading:20462459-DNA Replication,
pubmed-meshheading:20462459-Genome,
pubmed-meshheading:20462459-Genome, Fungal,
pubmed-meshheading:20462459-Genome, Human,
pubmed-meshheading:20462459-Genomics,
pubmed-meshheading:20462459-Humans,
pubmed-meshheading:20462459-Models, Statistical,
pubmed-meshheading:20462459-S Phase,
pubmed-meshheading:20462459-Saccharomyces cerevisiae,
pubmed-meshheading:20462459-Schizosaccharomyces
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pubmed:year |
2010
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pubmed:articleTitle |
Genome-wide estimation of firing efficiencies of origins of DNA replication from time-course copy number variation data.
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pubmed:affiliation |
Computational and Systems Biology, Genome Institute of Singapore, Biopolis, Republic of Singapore.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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