Linked Life Data

20460926

Source:http://linkedlifedata.com/resource/pubmed/id/20460926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-5-12
pubmed:abstractText
The pathogenesis of liver damage associated with the chronic hepatitis C virus (HCV) infection is largely immunomediated. However, some frequent histopathological features, such as fatty liver, suggest a direct cytopathic effect of HCV. The direct responsibility of HCV in the pathogenesis of steatosis is shown by: (1) the association with HCV genotype 3 infection, suggesting that some viral sequences are involved in the intracellular accumulation of triglycerides; (2) the correlation between the severity of steatosis and HCV replication levels; and (3) the association between the response to antivirals and the disappearance of steatosis. Experimental studies have shown that the core protein of HCV is capable and sufficient to induce a triglyceride accumulation in hepatocytes. Moreover, the observation that chronic hepatitis C patients have reduced serum levels of apolipoprotein B suggests an interference with the very-low-density lipoprotein assembly. In patients with a sustained virological response induced by antiviral therapy, such levels are normalized. Other observations suggest that HCV may increase neolipogenesis and inhibit fatty acid degradation in mitochondria. Put together, all of these mechanisms contribute to the pathogenesis of fatty liver frequently observed in hepatitis C.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1421-9875
pubmed:author
pubmed:copyrightInfo
Copyright 2010 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
294-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Hepatitis C virus-induced steatosis: an overview.
pubmed:affiliation
Division of Gastroenterology and Hepatology, University of Geneva Medical Center, Geneva, Switzerland. Francesco.Negro@hcuge.ch
pubmed:publicationType
Journal Article, Review