| pubmed-article:20460483 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20460483 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20460483 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:20460483 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20460483 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:20460483 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:20460483 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:20460483 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:20460483 | pubmed:dateCreated | 2010-5-14 | lld:pubmed |
| pubmed-article:20460483 | pubmed:abstractText | Blockade of CTL-associated antigen-4 (CTLA-4), an inhibitory immunomodulatory molecule on T cells, has been shown to enhance T-cell responses and induce tumor rejection, and a number of clinical trials with anti-CTLA-4 blocking monoclonal antibody (mAb) are under way. However, accumulating evidence indicates that anti-CTLA-4 mAb increases the number of CD4+CD25+Foxp3+ regulatory T cells (Treg) and that anti-CTLA4 mAb alone is often insufficient to reject established tumors in mice and humans. Thus, finding maneuvers to control Tregs and other immunosuppressive mechanisms remains a critical challenge. | lld:pubmed |
| pubmed-article:20460483 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20460483 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20460483 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20460483 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20460483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20460483 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20460483 | pubmed:month | May | lld:pubmed |
| pubmed-article:20460483 | pubmed:issn | 1078-0432 | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:ShikuHiroshiH | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:KondoSatoshiS | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:SakaguchiShim... | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:AllisonJames... | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:OldLloyd JLJ | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:WangLinanL | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:NishikawaHiro... | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:SatoEiichiE | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:KatoTakumaT | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:MitrevZanZ | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:MuraokaDaisuk... | lld:pubmed |
| pubmed-article:20460483 | pubmed:author | pubmed-author:NoguchiTakuro... | lld:pubmed |
| pubmed-article:20460483 | pubmed:copyrightInfo | Copyright (c) 2010 AACR. | lld:pubmed |
| pubmed-article:20460483 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:20460483 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20460483 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:20460483 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20460483 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20460483 | pubmed:pagination | 2781-91 | lld:pubmed |
| pubmed-article:20460483 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:20460483 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20460483 | pubmed:articleTitle | Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. | lld:pubmed |
| pubmed-article:20460483 | pubmed:affiliation | Department of Cancer Vaccine, Mie University Graduate School of Medicine, Mie, Japan. | lld:pubmed |
| pubmed-article:20460483 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20460483 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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