|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2010-5-14
|
|
pubmed:abstractText |
Blockade of CTL-associated antigen-4 (CTLA-4), an inhibitory immunomodulatory molecule on T cells, has been shown to enhance T-cell responses and induce tumor rejection, and a number of clinical trials with anti-CTLA-4 blocking monoclonal antibody (mAb) are under way. However, accumulating evidence indicates that anti-CTLA-4 mAb increases the number of CD4+CD25+Foxp3+ regulatory T cells (Treg) and that anti-CTLA4 mAb alone is often insufficient to reject established tumors in mice and humans. Thus, finding maneuvers to control Tregs and other immunosuppressive mechanisms remains a critical challenge.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoid-Induced...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf18 protein, mouse
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
pubmed-author:AllisonJames PJP,
pubmed-author:KatoTakumaT,
pubmed-author:KondoSatoshiS,
pubmed-author:MitrevZanZ,
pubmed-author:MuraokaDaisukeD,
pubmed-author:NishikawaHiroyoshiH,
pubmed-author:NoguchiTakuroT,
pubmed-author:OldLloyd JLJ,
pubmed-author:SakaguchiShimonS,
pubmed-author:SatoEiichiE,
pubmed-author:ShikuHiroshiH,
pubmed-author:WangLinanL
|
|
pubmed:copyrightInfo |
Copyright (c) 2010 AACR.
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2781-91
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:20460483-Animals,
pubmed-meshheading:20460483-Antibodies, Monoclonal,
pubmed-meshheading:20460483-Antigens, CD,
pubmed-meshheading:20460483-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:20460483-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20460483-CTLA-4 Antigen,
pubmed-meshheading:20460483-Cell Separation,
pubmed-meshheading:20460483-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20460483-Female,
pubmed-meshheading:20460483-Flow Cytometry,
pubmed-meshheading:20460483-Glucocorticoid-Induced TNFR-Related Protein,
pubmed-meshheading:20460483-Immunohistochemistry,
pubmed-meshheading:20460483-Immunologic Factors,
pubmed-meshheading:20460483-Immunomodulation,
pubmed-meshheading:20460483-Lymphocyte Activation,
pubmed-meshheading:20460483-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:20460483-Mice,
pubmed-meshheading:20460483-Mice, Inbred BALB C,
pubmed-meshheading:20460483-Neoplasms, Experimental,
pubmed-meshheading:20460483-Receptors, Nerve Growth Factor,
pubmed-meshheading:20460483-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:20460483-T-Lymphocytes, Regulatory
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.
|
|
pubmed:affiliation |
Department of Cancer Vaccine, Mie University Graduate School of Medicine, Mie, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
