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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-6-18
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pubmed:abstractText |
Activator protein-2 (AP-2) transcription factors are critically involved in a variety of fundamental cellular processes such as proliferation, differentiation and apoptosis and have also been implicated in carcinogenesis. Expression of the family members AP-2alpha and AP-2gamma is particularly well documented in malignancies of the female breast. Despite increasing evaluation of single AP-2 isoforms in mammary tumors the functional role of concerted expression of multiple AP-2 isoforms in breast cancer remains to be elucidated. AP-2 proteins can form homo- or heterodimers, and there is growing evidence that the net effect whether a cell will proliferate, undergo apoptosis or differentiate is partly dependent on the balance between different AP-2 isoforms.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
192
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20459791-Animals,
pubmed-meshheading:20459791-Antineoplastic Agents,
pubmed-meshheading:20459791-Apoptosis,
pubmed-meshheading:20459791-Cell Line, Tumor,
pubmed-meshheading:20459791-Databases, Genetic,
pubmed-meshheading:20459791-Drug Resistance, Neoplasm,
pubmed-meshheading:20459791-Female,
pubmed-meshheading:20459791-Gene Expression Profiling,
pubmed-meshheading:20459791-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20459791-Gene Regulatory Networks,
pubmed-meshheading:20459791-Mammary Neoplasms, Experimental,
pubmed-meshheading:20459791-Mice,
pubmed-meshheading:20459791-Mutation,
pubmed-meshheading:20459791-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20459791-Protein Isoforms,
pubmed-meshheading:20459791-Radiation Tolerance,
pubmed-meshheading:20459791-Receptor, erbB-2,
pubmed-meshheading:20459791-Transcription Factor AP-2,
pubmed-meshheading:20459791-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells.
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pubmed:affiliation |
Department of Developmental Pathology, Institute of Pathology, University of Bonn, Medical School, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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