|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2010-6-1
|
|
pubmed:abstractText |
The reaction of the ruthenium(II) complex fac-[Ru(CO)(3)Cl(2)(N(1)-thz)] (I hereafter; thz = 1,3-thiazole) with human beta-amyloid peptide 1-28 (Abeta(28)) and the resulting {Ru(CO)(3)}(2+) peptide adduct was investigated by a variety of biophysical methods. (1)H NMR titrations highlighted a selective interaction of {Ru(CO)(3)}(2+) with Abeta(28) histidine residues; circular dichroism revealed the occurrence of a substantial conformational rearrangement of Abeta(28); electrospray ionization mass spectrometry (ESI-MS) suggested a prevalent 1:1 metal/peptide stoichiometry and disclosed the nature of peptide-bound metallic fragments. Notably, very similar ESI-MS results were obtained when I was reacted with Abeta(42). The implications of the above findings for a possible use of ruthenium compounds in Alzheimer's disease are discussed.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1520-510X
|
|
pubmed:author |
pubmed-author:AnziniPaoloP,
pubmed-author:CiniRenzoR,
pubmed-author:GabbianiChiaraC,
pubmed-author:GaggelliElenaE,
pubmed-author:GaggelliNicolaN,
pubmed-author:KozlowskiHenrykH,
pubmed-author:MessoriLuigiL,
pubmed-author:MichelucciElenaE,
pubmed-author:TamasiGabriellaG,
pubmed-author:ValensinDanielaD,
pubmed-author:ValensinGianniG
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
7
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4720-2
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:20459130-Alzheimer Disease,
pubmed-meshheading:20459130-Amyloid beta-Peptides,
pubmed-meshheading:20459130-Circular Dichroism,
pubmed-meshheading:20459130-Drug Design,
pubmed-meshheading:20459130-Histidine,
pubmed-meshheading:20459130-Humans,
pubmed-meshheading:20459130-Magnetic Resonance Spectroscopy,
pubmed-meshheading:20459130-Molecular Conformation,
pubmed-meshheading:20459130-Organometallic Compounds,
pubmed-meshheading:20459130-Peptide Fragments,
pubmed-meshheading:20459130-Ruthenium,
pubmed-meshheading:20459130-Spectrometry, Mass, Electrospray Ionization
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
fac-{Ru(CO)(3)}(2+) selectively targets the histidine residues of the beta-amyloid peptide 1-28. Implications for new Alzheimer's disease treatments based on ruthenium complexes.
|
|
pubmed:affiliation |
Department of Chemistry, University of Siena, Via A. Moro, 53100 Siena, Italy.
|
|
pubmed:publicationType |
Journal Article
|
