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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-9-15
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pubmed:abstractText |
D-type cyclins predominantly regulate progression through the cell cycle by their interactions with cyclin-dependent kinases (cdks). Here, we show that stimulating mitogenesis of Swiss 3T3 cells with phorbol esters or forskolin can induce divergent responses in the expression levels, localization and activation state of cyclin D1 and cyclin D3. Phorbol ester-mediated protein kinase C stimulation induces S phase entry which is dependent on MAPK activation and increases the levels and activation of cyclin D1, whereas forskolin-mediated cAMP-dependent protein kinase A stimulation induces mitogenesis that is independent of MAPK, but dependent upon mTor and specifically increases the level and activation of cyclin D3. These findings uncover additional levels of complexity in the regulation of the cell cycle at the level of the D-type cyclins and thus may have important therapeutic implications in cancers where specific D-cyclins are overexpressed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCND3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ccnd1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ccnd3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D3,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol 12,13-Dibutyrate,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/mTOR protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1097-4652
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
225
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
638-45
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20458731-Animals,
pubmed-meshheading:20458731-Cyclic AMP,
pubmed-meshheading:20458731-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:20458731-Cyclin D1,
pubmed-meshheading:20458731-Cyclin D3,
pubmed-meshheading:20458731-Cyclin-Dependent Kinase 4,
pubmed-meshheading:20458731-Enzyme Activation,
pubmed-meshheading:20458731-Enzyme Activators,
pubmed-meshheading:20458731-Fibroblasts,
pubmed-meshheading:20458731-Forskolin,
pubmed-meshheading:20458731-Humans,
pubmed-meshheading:20458731-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20458731-Mice,
pubmed-meshheading:20458731-Mitogen-Activated Protein Kinases,
pubmed-meshheading:20458731-Mitogens,
pubmed-meshheading:20458731-Mitosis,
pubmed-meshheading:20458731-Phorbol 12,13-Dibutyrate,
pubmed-meshheading:20458731-Protein Kinase C,
pubmed-meshheading:20458731-Protein Kinase Inhibitors,
pubmed-meshheading:20458731-Protein Transport,
pubmed-meshheading:20458731-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20458731-Signal Transduction,
pubmed-meshheading:20458731-Sirolimus,
pubmed-meshheading:20458731-Swiss 3T3 Cells,
pubmed-meshheading:20458731-TOR Serine-Threonine Kinases,
pubmed-meshheading:20458731-Time Factors,
pubmed-meshheading:20458731-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Cyclin D1 and cyclin D3 show divergent responses to distinct mitogenic stimulation.
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pubmed:affiliation |
Division of Cell and Molecular Biology, Imperial College London, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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