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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-13
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pubmed:abstractText |
Kidney toxicity accounts both for the failure of many drug candidates as well as considerable patient morbidity. Whereas histopathology remains the gold standard for nephrotoxicity in animal systems, serum creatinine (SCr) and blood urea nitrogen (BUN) are the primary options for monitoring kidney dysfunction in humans. The transmembrane tubular protein kidney injury molecule-1 (Kim-1) was previously reported to be markedly induced in response to renal injury. Owing to the poor sensitivity and specificity of SCr and BUN, we used rat toxicology studies to compare the diagnostic performance of urinary Kim-1 to BUN, SCr and urinary N-acetyl-beta-D-glucosaminidase (NAG) as predictors of kidney tubular damage scored by histopathology. Kim-1 outperforms SCr, BUN and urinary NAG in multiple rat models of kidney injury. Urinary Kim-1 measurements may facilitate sensitive, specific and accurate prediction of human nephrotoxicity in preclinical drug screens. This should enable early identification and elimination of compounds that are potentially nephrotoxic.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylglucosaminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Biomarkers, Pharmacological,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Gentamicins,
http://linkedlifedata.com/resource/pubmed/chemical/Havcr1protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Thioacetamide
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1546-1696
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pubmed:author |
pubmed-author:BobadillaNorma ANA,
pubmed-author:BonventreJoseph VJV,
pubmed-author:CollingsFitz BFB,
pubmed-author:CordierAndréA,
pubmed-author:DieterleFrankF,
pubmed-author:GerholdDavidD,
pubmed-author:GoeringPeter LPL,
pubmed-author:HolderDaniel JDJ,
pubmed-author:MarrerEstelleE,
pubmed-author:MaurerGérardG,
pubmed-author:MuniappaNagarajaN,
pubmed-author:OzerJosef SJS,
pubmed-author:PerentesEliasE,
pubmed-author:RamirezVictoriaV,
pubmed-author:SistareFrank DFD,
pubmed-author:ThudiumDouglasD,
pubmed-author:TrothSeanS,
pubmed-author:VaidyaVishal SVS,
pubmed-author:VonderscherJackyJ
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
478-85
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20458318-Acetylglucosaminidase,
pubmed-meshheading:20458318-Animals,
pubmed-meshheading:20458318-Biomarkers, Pharmacological,
pubmed-meshheading:20458318-Blood Urea Nitrogen,
pubmed-meshheading:20458318-Cell Adhesion Molecules,
pubmed-meshheading:20458318-Cisplatin,
pubmed-meshheading:20458318-Creatinine,
pubmed-meshheading:20458318-Cyclosporine,
pubmed-meshheading:20458318-Drug Evaluation, Preclinical,
pubmed-meshheading:20458318-Drug Toxicity,
pubmed-meshheading:20458318-Gentamicins,
pubmed-meshheading:20458318-Histocytochemistry,
pubmed-meshheading:20458318-Kidney,
pubmed-meshheading:20458318-Kidney Function Tests,
pubmed-meshheading:20458318-Male,
pubmed-meshheading:20458318-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20458318-ROC Curve,
pubmed-meshheading:20458318-Rats,
pubmed-meshheading:20458318-Rats, Sprague-Dawley,
pubmed-meshheading:20458318-Rats, Wistar,
pubmed-meshheading:20458318-Reperfusion Injury,
pubmed-meshheading:20458318-Thioacetamide
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pubmed:year |
2010
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pubmed:articleTitle |
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.
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pubmed:affiliation |
Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. vvaidya@partners.org
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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