| pubmed-article:20457807 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20457807 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:20457807 | lifeskim:mentions | umls-concept:C1366544 | lld:lifeskim |
| pubmed-article:20457807 | lifeskim:mentions | umls-concept:C0314672 | lld:lifeskim |
| pubmed-article:20457807 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:20457807 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:20457807 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20457807 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:20457807 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:20457807 | pubmed:dateCreated | 2010-6-25 | lld:pubmed |
| pubmed-article:20457807 | pubmed:abstractText | The receptor tyrosine kinase Ror2 acts as a receptor or coreceptor for Wnt5a to mediate Wnt5a-induced activation of the Wnt/JNK pathway and inhibition of the beta-catenin-dependent canonical Wnt pathway. However, little is known about how Ror2 cooperates with another receptor component(s) to mediate Wnt5a signaling. We show here that Ror2 regulates Wnt5a-induced polymerization of Dishevelled (Dvl) and that this Ror2-mediated regulation of Dvl is independent of the cytoplasmic region of Ror2. Ror2 can associate with Frizzled7 (Fz7) via its extracellular cysteine-rich domain to form a receptor complex that is required for the regulation of Dvl and activation of the AP-1 promoter after Wnt5a stimulation. Suppressed expression of Fz7 indeed results in the inhibition of Wnt5a-induced polymerization of Dvl and AP-1 activation. Interestingly, both the DIX and the DEP domains of Dvl are indispensable for Dvl polymerization and subsequent AP-1 activation after Wnt5a stimulation. We further show that polymerized Dvl is colocalized with Rac1 and that suppressed expression of Rac1 inhibits Wnt5a-induced AP-1 activation. Collectively, our results indicate that Ror2/Fz receptor complex plays an important role in the Wnt5a/Rac1/AP-1 pathway by regulating the polymerization of Dvl. | lld:pubmed |
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| pubmed-article:20457807 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20457807 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457807 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20457807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20457807 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20457807 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20457807 | pubmed:issn | 1098-5549 | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:PoweL KLK | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:KikuchiAkiraA | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:TakadaShinjiS | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:MinamiYasuhir... | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:NishitaMichir... | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:InabaDaisukeD | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:EndoMitsuharu... | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:NomachiAkiraA | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:WangZhiChaoZ | lld:pubmed |
| pubmed-article:20457807 | pubmed:author | pubmed-author:ItsukushimaSu... | lld:pubmed |
| pubmed-article:20457807 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20457807 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:20457807 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20457807 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20457807 | pubmed:pagination | 3610-9 | lld:pubmed |
| pubmed-article:20457807 | pubmed:dateRevised | 2011-7-19 | lld:pubmed |
| pubmed-article:20457807 | pubmed:meshHeading | pubmed-meshheading:20457807... | lld:pubmed |
| pubmed-article:20457807 | pubmed:meshHeading | pubmed-meshheading:20457807... | lld:pubmed |
