|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
14
|
|
pubmed:dateCreated |
2010-6-25
|
|
pubmed:abstractText |
The receptor tyrosine kinase Ror2 acts as a receptor or coreceptor for Wnt5a to mediate Wnt5a-induced activation of the Wnt/JNK pathway and inhibition of the beta-catenin-dependent canonical Wnt pathway. However, little is known about how Ror2 cooperates with another receptor component(s) to mediate Wnt5a signaling. We show here that Ror2 regulates Wnt5a-induced polymerization of Dishevelled (Dvl) and that this Ror2-mediated regulation of Dvl is independent of the cytoplasmic region of Ror2. Ror2 can associate with Frizzled7 (Fz7) via its extracellular cysteine-rich domain to form a receptor complex that is required for the regulation of Dvl and activation of the AP-1 promoter after Wnt5a stimulation. Suppressed expression of Fz7 indeed results in the inhibition of Wnt5a-induced polymerization of Dvl and AP-1 activation. Interestingly, both the DIX and the DEP domains of Dvl are indispensable for Dvl polymerization and subsequent AP-1 activation after Wnt5a stimulation. We further show that polymerized Dvl is colocalized with Rac1 and that suppressed expression of Rac1 inhibits Wnt5a-induced AP-1 activation. Collectively, our results indicate that Ror2/Fz receptor complex plays an important role in the Wnt5a/Rac1/AP-1 pathway by regulating the polymerization of Dvl.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-10231392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-10476968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-10651906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-10727861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-10769031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-10862746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-11231145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-11429290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-11970895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-12754255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-12839624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-14617821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-14651925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-14688793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-15173592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-15375164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-15944127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-16115200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-16263761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-16263762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-16569699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-16602827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-17005174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-17101698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-17199046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-17244647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-17488628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-17529994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-17606995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-17717073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-17942487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-18215320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-18365018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-18606138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-18614017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-18667433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-18724937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-18948417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-19530173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-19536106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-19561603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-19561643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-19619488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-19720827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-19736321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-19910923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-3803719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-9674432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20457807-9716412
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Fzd7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Multiprotein Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Rac1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Tyrosine Kinase-like...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ror2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt5a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/dishevelled proteins,
http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1098-5549
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
30
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3610-9
|
|
pubmed:dateRevised |
2011-7-19
|
|
pubmed:meshHeading |
|
