Linked Life Data

2045466

Source:http://linkedlifedata.com/resource/pubmed/id/2045466

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-7-12
pubmed:abstractText
The transition from a high carbohydrate to a high fat diet may explain in part the dramatic increase in the prevalence of noninsulin-dependent diabetes mellitus among Pima Indians over the last century. In this study, 12 Pimas and 12 caucasians, all nondiabetic, were admitted to a metabolic ward and, in random order, fed 2 14-day weight-maintaining diets: a traditional Pima diet (percentage of calories: carbohydrate, 70% fat, 15%; protein, 15%) and a high fat modern diet (carbohydrate, 30%; fat, 50%; protein, 20%). Carbohydrate metabolism was characterized using the modified iv glucose tolerance test (minimal model), the acute insulin responses to arginine during a 3-step glycemic clamp, and the oral glucose tolerance test. Compared with the traditional diet, the modern diet was associated with a decrease in oral glucose tolerance (P less than 0.01) and higher plasma cholesterol concentrations (P less than 0.02). The decline in glucose tolerance was associated with similar insulin-mediated, but 23% lower glucose-mediated (P less than 0.001), glucose disposal, a 17% lower acute insulin response to glucose (P less than 0.03), a 9% lower beta-cell sensitivity to glucose (P less than 0.02), and similar beta-cell capacities. Pimas and caucasians responded similarly, except for larger changes in plasma lipids among the Pimas. Since glucose-mediated glucose disposal, beta-cell function, and glucose tolerance deteriorated on the modern diet, it is likely that diet composition affects the prevalence of noninsulin-dependent diabetes mellitus in both Pimas and caucasians.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
156-65
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:2045466-Adult, pubmed-meshheading:2045466-Arginine, pubmed-meshheading:2045466-Blood Glucose, pubmed-meshheading:2045466-Cholesterol, pubmed-meshheading:2045466-Dietary Carbohydrates, pubmed-meshheading:2045466-Dietary Fats, pubmed-meshheading:2045466-Dietary Proteins, pubmed-meshheading:2045466-Energy Intake, pubmed-meshheading:2045466-European Continental Ancestry Group, pubmed-meshheading:2045466-Female, pubmed-meshheading:2045466-Glucose Clamp Technique, pubmed-meshheading:2045466-Glucose Tolerance Test, pubmed-meshheading:2045466-Humans, pubmed-meshheading:2045466-Indians, North American, pubmed-meshheading:2045466-Insulin, pubmed-meshheading:2045466-Lipoproteins, pubmed-meshheading:2045466-Lipoproteins, HDL, pubmed-meshheading:2045466-Lipoproteins, LDL, pubmed-meshheading:2045466-Male, pubmed-meshheading:2045466-Triglycerides
pubmed:year
1991
pubmed:articleTitle
Deterioration in carbohydrate metabolism and lipoprotein changes induced by modern, high fat diet in Pima Indians and Caucasians.
pubmed:affiliation
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial