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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-7-17
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pubmed:databankReference |
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pubmed:abstractText |
The spatial and temporal expression pattern of the muscle regulatory gene Myf-6 (MRF4/herculin) has been investigated by in situ hybridization during embryonic and fetal mouse development. Here, we report that the Myf-6 gene shows a biphasic pattern of expression. Myf-6 transcripts are first detected in the most rostral somites of the mouse embryo at 9 d of gestation and accumulate progressively in myotomal cells along the rostro-caudal axis. This expression is transient and Myf-6 mRNA can no longer be detected in myotomal cells after day 12 post coitum (p.c.). In contrast to other muscle determination genes (MyoD1, myogenin, Myf-5), Myf-6 mRNA is not detected in limb buds or visceral arches and skeletal muscle of the mouse embryo (day 8-15 p.c.). In fetal mice, Myf-6 transcripts appear at day 16 p.c. in all skeletal muscles, and the gene continues to be expressed at a high level after birth. These results suggest that early Myf-6 expression may be restricted to a population of myogenic cells that does not contribute to the embryonic muscle masses in limb buds and visceral arches. The reappearance of Myf-6 mRNA in fetal skeletal muscle coincides approximately with secondary muscle fiber formation and the onset of innervation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-1020950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-1695319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2156629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2167895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2211821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2243772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2253873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2300571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2311584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2385294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2451450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2473006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2503252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2537150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2546677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2552320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2560751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2583111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2721498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2748593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-2777078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-3690668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-3743898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-525819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-5613322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-6194404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-6235151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-6496372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2045411-6772444
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9525
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
113
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pubmed:geneSymbol |
Myf-6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1255-65
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2045411-Base Sequence,
pubmed-meshheading:2045411-Blotting, Northern,
pubmed-meshheading:2045411-DNA,
pubmed-meshheading:2045411-Gene Expression Regulation,
pubmed-meshheading:2045411-Genes, Regulator,
pubmed-meshheading:2045411-Humans,
pubmed-meshheading:2045411-Molecular Sequence Data,
pubmed-meshheading:2045411-Muscle Development,
pubmed-meshheading:2045411-Muscle Proteins,
pubmed-meshheading:2045411-Muscles,
pubmed-meshheading:2045411-Myogenic Regulatory Factors,
pubmed-meshheading:2045411-Myogenin,
pubmed-meshheading:2045411-Nucleic Acid Hybridization
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pubmed:year |
1991
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pubmed:articleTitle |
The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development.
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pubmed:affiliation |
Department of Toxicology, Medical School, University of Hamburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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