Linked Life Data

20453297

Source:http://linkedlifedata.com/resource/pubmed/id/20453297

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-5-10
pubmed:abstractText
Chemotaxis is typically modeled in the context of cellular motion toward a static, exogenous source of chemoattractant. Here we propose a time-dependent mechanism of chemotaxis in which a self-propelled particle (e.g. a cell) releases a chemical that diffuses to fixed particles (targets) and signals the production of a second chemical by these targets. The particle then moves up concentration gradients of this second chemical, analogous to diffusive echolocation. When one target is present, we describe probe release strategies that optimize travel of the cell to the target. In the presence of multiple targets, the one selected by the cell depends on the strength and, interestingly, on the frequency of probe chemical release. Although involving an additional chemical signaling step, our chemical 'pinging' hypothesis allows for greater flexibility in regulating target selection, as seen in a number of physical or biological realizations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1478-3975
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
026003
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Frequency-dependent chemolocation and chemotactic target selection.
pubmed:affiliation
Department of Biomathematics, UCLA, Los Angeles, CA 90095-1766, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural