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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2010-8-30
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pubmed:abstractText |
Many studies including our previous ones as to PROKR2 and CLOCK have suggested that circadian genes may be involved in the mechanisms of mood disorders and their treatment responses. Also several recent investigations have reported that SIRT1 plays an important role in the circadian system as conventional circadian clock genes, and also have some relation to dopaminergic metabolism. So we considered the SIRT1 gene to be a good candidate gene for the pathophysiology for MDD and SSRI responses in MDD, and conducted a case-control study using four tagging SNPs (450 MDD patients, including 261 patients treated by SSRIs and 766 controls).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1573-2517
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pubmed:author |
pubmed-author:FukuoYasuhisaY,
pubmed-author:InadaToshiyaT,
pubmed-author:IwataNakaoN,
pubmed-author:KawashimaKunihiroK,
pubmed-author:KinoshitaYokoY,
pubmed-author:KishiTaroT,
pubmed-author:KitajimaTsuyoshiT,
pubmed-author:NaitohHiroshiH,
pubmed-author:NakamuraJunJ,
pubmed-author:OkochiTomoT,
pubmed-author:OkumuraTakenoriT,
pubmed-author:OzakiNorioN,
pubmed-author:TsunokaTomokoT,
pubmed-author:Umene-NakanoWakakoW,
pubmed-author:YamanouchiYoshioY,
pubmed-author:YoshimuraReijiR
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pubmed:copyrightInfo |
Copyright 2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-73
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pubmed:meshHeading |
pubmed-meshheading:20451257-Alleles,
pubmed-meshheading:20451257-Depressive Disorder, Major,
pubmed-meshheading:20451257-Female,
pubmed-meshheading:20451257-Genetic Association Studies,
pubmed-meshheading:20451257-Genotype,
pubmed-meshheading:20451257-Haplotypes,
pubmed-meshheading:20451257-Humans,
pubmed-meshheading:20451257-Japan,
pubmed-meshheading:20451257-Male,
pubmed-meshheading:20451257-Middle Aged,
pubmed-meshheading:20451257-Polymorphism, Single Nucleotide,
pubmed-meshheading:20451257-Psychiatric Status Rating Scales,
pubmed-meshheading:20451257-Serotonin Uptake Inhibitors,
pubmed-meshheading:20451257-Sirtuin 1,
pubmed-meshheading:20451257-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
SIRT1 gene is associated with major depressive disorder in the Japanese population.
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pubmed:affiliation |
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. tarok@fujita-hu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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