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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-7-12
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pubmed:databankReference |
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pubmed:abstractText |
The retroviral integration site Fli-1 is rearranged in 75% of the erythroleukemia cell clones induced by Friend murine leukemia virus (F-MuLV), whereas Spi-1/PU.1, a member of the ets family of DNA-binding proteins, is rearranged in 95% of the erythroleukemias induced by Friend spleen focus-forming virus (SFFV). To determine the transcriptional domain defined by Fli-1, we have isolated a cDNA clone that is highly expressed only in erythroleukemia cell lines with Fli-1 rearrangements. The protein sequence of this cDNA is very similar to Erg2, another member of the ets gene family. The hydrophilic carboxy-terminal end of the Fli-1 cDNA shares significant sequence similarity to the DNA-binding ETS domain found in all members of the ets family. PFGE analysis localized Fli-1 within 240 kb of the ets-1 proto-oncogene on mouse chromosome 9 and human chromosome 11q23, suggesting that ets-1 and Fli-1 arose from a common ancestral gene by gene duplication. The involvement of the murine Fli-1, Spi-1, and avian v-ets genes in erythroleukemia induction suggests that activation of ets gene family members plays an important role in the progression of these multistage malignancies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:geneSymbol |
ets,
ets-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
908-18
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2044959-Amino Acid Sequence,
pubmed-meshheading:2044959-Animals,
pubmed-meshheading:2044959-Base Sequence,
pubmed-meshheading:2044959-Blotting, Northern,
pubmed-meshheading:2044959-Cell Transformation, Neoplastic,
pubmed-meshheading:2044959-Cell Transformation, Viral,
pubmed-meshheading:2044959-DNA,
pubmed-meshheading:2044959-Friend murine leukemia virus,
pubmed-meshheading:2044959-Genetic Linkage,
pubmed-meshheading:2044959-Hematopoiesis,
pubmed-meshheading:2044959-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:2044959-Mice,
pubmed-meshheading:2044959-Molecular Sequence Data,
pubmed-meshheading:2044959-Multigene Family,
pubmed-meshheading:2044959-Proto-Oncogene Protein c-ets-1,
pubmed-meshheading:2044959-Proto-Oncogene Proteins,
pubmed-meshheading:2044959-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:2044959-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:2044959-Transcription, Genetic,
pubmed-meshheading:2044959-Transcription Factors,
pubmed-meshheading:2044959-Tumor Cells, Cultured
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pubmed:year |
1991
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pubmed:articleTitle |
Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1.
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pubmed:affiliation |
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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